Alhaji Lai Mohammed as a Lawyer co-founded the legal firm of Edu & Mohammed as a Senior Partner in 1989. He is an astute Businessman and an active politician. Even with his appointment as the Minister of Information and Culture, the All Progressive Congress (APC) which he has been serving as its National Publicity Secretary, is yet to announce a replacement to the indefatigable publicity secretary.
Alhaji Mohammed served as the Chairman of Optmedia Limited, a subsidiary of Afromedia Plc. since December 18, 2008. He served as a Director of Afromedia Plc. since May 2011.
Alhaji Mohammed is also a fellow of the Nigerian Institute of Public Relations (NIPR) and worked as Public Relations Officer for almost 10 years with the Nigerian Airport Authority, now Federal Airport Authority of Nigeria (FAAN).
In October 2002, Alhaji Lai Mohammed was a candidate for governor in the April 2003 Kwara State elections on the Alliance for Democracy platform.